To evaluate early dynamic contrast enhancement CT on multiple organ failure in acute pancreatitis / 实用放射学杂志

Objective To evaluate early dynamic contrast enhancement CT on multiple organ failure in acute pancreatitis.Methods 333 cases of acute pancreatitis identified by clinical and early dynamic contrast enhancement CT were collected.Patients were divided into organ failure group(OF group,124 cases) and non-organ failure group (notn-OF group,209 cases).All variables including duration of hospitalization,need for intensive care unit,infection,need for operation,mortality and MCTSI,EPIC score were analyzed by U test and x2 test firstly.The variables with significance (P＜0.05) were analyzed by Stepwise Logistic regression further.Results On U test and x2 test,there were significant differences(P＜0.001) between two groups in duration of hospitalization,need for intensive care unit,infection,need for operation,mortality,MCTSI score and EPIC score and APFC + ANC＞ 100 mL,and bilateral pleural effusion/ pulmonary atelectasis.The Stepwise Logistic regression analysis demonstrated that increased MCTSI and EPIC score,APFC+ANC＞ 100 mL and bilateral pleural effusion/pulmonary atelectasis were 4 independent risk factors of multiple organ failure in acute pancreatitis.Conclusion Multiple organ failure in acute pancreatitis can be judged with early dynamic contrast enhancement CT for improved treatment.

To evaluate hepatic functional reserve and operational risks of primary hepatic carcinoma in Child A using functional CT / 实用放射学杂志

Objective To evaluate hepatic functional reserve and operational risks of primary hepatic carcinoma in Child A using functional CT.Methods In 128 cases of primary hepatic carcinoma of Child A undergoing hepatoectomy and identified by pathology, CT perfusion scanning and measurement of remannent hepatic volume were done before operation and whole patients were divided in-to acute hepatic failure group(AHF group,33 cases)and non-acute hepatic failure(non-AHF group,95 cases).All variables were ana-lyzed by one way analysis of variance(one-way ANOVA)firstly.The variables with significance (P<0.05)were analyzed with Step-wise Logistic regression further.Results One-way ANOVA result:There were significant difference between two groups in RHVS measured by CT,PVP,HBF,HBV,serum creatinine,thrombinogen activity,total bilirubin and intraoperative blood loss (P<0.05).The StepwiseLogistic regression analysis demonstrated that decreased RHVS and the lowed PVP were the independent risk factors of AHF complicated to hepatoectomy of primary hepatic carcinoma(P<0.01).Conclusion Hepatic functional reserve and operational risks of primary hepatic carcinoma could be j udged with functional CT before operation .

Multi-slice CT Perfusion Study on Angiogenesis in Hepatocellular Carcinoma Induced by Hypoxia Inducible Factor-1? / 实用放射学杂志

Objective To study the correlation between multi-slice CT perfusion imaging and angiogenesis in hepatocellular carcinoma(HCC) induced by hypoxia inducible factor-1?(HIF-1?).Methods Multi-slice CT perfusion data were obtained in 34 cases of HCC and 11 cases of hepatic hemangioma identified by operation and pathology.Positive expression of HIF-1? and vascular endothelial growth factor(VEGF) protein of the lesions in all cases and surrounding normal hepatic tissue were investigated with SP immunohistochemistry.Microvessel density(MVD) was determined by anti-CD34 immunostaining.The correlation between multi-slice CT perfusion data and positive expression of HIF-1?,VEGF and CD34 was investigated simultaneously.Results Hepatic arterial perfusion(HAP) and hepatic arterial perfusion index(HAI) in HCC were higher than that of hepatic hemangioma and surrounding normal hepatic tissue(P